Ibrutinib-nicotinic acid eutectic crystal and preparation method thereof

The invention belongs to the technical field of crystal form drug molecules, and particularly provides an ibrutinib-nicotinic acid eutectic crystal. The ibrutinib-nicotinic acid eutectic prepared by the invention is radiated by Cu-K alpha, and an X-ray diffraction pattern expressed by 2 theta has characteristic peaks at the positions of 5.46 +/-0.2 degrees, 15.22 +/-0.2 degrees, 20.10 +/-0.2 degrees, 20.97 +/-0.2 degrees, 24.57 +/-0.2 degrees, 25.71 +/-0.2 degrees, 26.78 +/-0.2 degrees and 27.76 +/-0.2 degrees. The method for preparing the ibrutinib-nicotinic acid eutectic crystal provided by the invention is simple to operate, and the prepared crystal is high in yield and purity. The ibrutinib-nicotinic acid eutectic crystal prepared by the invention has relatively good chemical stability and relatively good solubility, and is of great significance for improving the bioavailability and the drug effect of ibrutinib. 本发明属于晶型药物分子技术领域，具体提供了一种伊布替尼-烟酸共晶。本发明制备的伊布替尼-烟酸共晶使用Cu-Kα辐射，以2θ表示的X射线衍射谱图在5.46±0.2°，15.22±0.2°，2