Anti-adhesion material

Provided is an anti-adhesion material which has improved tissue adhesion and biodegradability, while having workability for affixing the anti-adhesion material to a biological tissue. The anti-adhesion material comprises a water-soluble support layer which contains a water-soluble polymer and has a...

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Hauptverfasser: SAITO AKIHIRO, SUZUKI AI, TAKEOKA SHINJI, ISHIZUKA YUYA, TANAHASHI KAZUHIRO, OKABAYASHI TSUYOSHI, NAKANISHI MEGUMI, FUJIE TOSHINORI, OTSUBO SHINYA, ARAKANE TORU, HOCHI MOTONORI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Provided is an anti-adhesion material which has improved tissue adhesion and biodegradability, while having workability for affixing the anti-adhesion material to a biological tissue. The anti-adhesion material comprises a water-soluble support layer which contains a water-soluble polymer and has a thickness of 1-1000 [mu] m, and an anti-adhesion layer which contains a biodegradable polymer and has a thickness of 1-1000 [mu] m, and is characterized in that: the biodegradable polymer has a structure in which a branched polyalkylene glycol and a polyhydroxyalkanoic acid are bonded; the mass ratio of the branched polyalkylene glycol to the total mass is 1-30%, and the branched polyalkylene glycol has 3-8 terminal hydroxyl groups per molecule. 提供具有可切实地贴附于生物体组织上的操作性、且组织密合性和生物降解性得到改善的防粘连材料。防粘连材料,其具有包含水溶性聚合物的厚度为1~1000μm的水溶性支撑层、和包含生物降解性聚合物且厚度为1~1000μm的防粘连层,上述生物降解性聚合物具有支链型聚亚烷基二醇与聚羟基烷酸键合而成的结构,且上述支链型聚亚烷基二醇相对于总质量的质量比率为1~30%,所述支链型聚亚烷基二醇每1分子具有3~8个末端羟基。