Application of acetamide compound as glutamate dehydrogenase inhibitor

The invention provides an application of an acetamide compound (S)-2-(2-(1-H-indole-3-yl) acetamido)-N, 2-bis (4-methoxyphenyl) acetamide as a glutamate dehydrogenase (GDH) inhibitor, a preparation method of the acetamide compound, and a preparation method of the acetamide compound. The compound has an effective inhibition effect on the activity of glutamate dehydrogenase (GDH) under the condition of micromolar concentration, and can be used for preparing a medicine for preventing and treating diseases caused by the GDH. Glutamate dehydrogenase is a mitochondrial enzyme, and is a key enzyme for glutamic acid to enter tricarboxylic acid cycle to generate ATP (adenosine triphosphate). According to the present invention, the functional mutation of GDH is one of the reasons for the generation of the congenital hyperinsulinemia (CHI) in the newborn, and the generation of the functional mutation of GDH in the newborn is the one of the reasons for the generation of the congenital hyperinsulinemia (CHI) in the newbor