Cx43 expression related biomolecule, sepsis treatment target and prognostic marker

The embodiment of the invention provides a biomolecule related to Cx43 expression, a sepsis treatment target and a sepsis prognosis marker. Wherein the biomolecule comprises a sequence as shown in SEQ ID No. 1; or at least one basic group in the sequence as shown in SEQ ID No.1 is varied, and the se...

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Bibliographische Detailangaben
Hauptverfasser:	WANG WEI, LI FURONG, CHEN HUAISHENG, HONG CHENGYING, LIU XUEYAN, LIU FEIYUAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The embodiment of the invention provides a biomolecule related to Cx43 expression, a sepsis treatment target and a sepsis prognosis marker. Wherein the biomolecule comprises a sequence as shown in SEQ ID No. 1; or at least one basic group in the sequence as shown in SEQ ID No.1 is varied, and the sequence as shown in SEQ ID No.1 has a variation sequence acting on the same target molecule; 1, or an RNA fragment containing a sequence as shown in SEQ ID No. 1 or a variant sequence of the sequence as shown in SEQ ID No. 1. The biomolecule is related to expression of Cx43, participates in a molecular regulation mechanism of sepsis, and can be used as a sepsis treatment target or a prognostic marker of sepsis. 本发明实施例提供了一种与Cx43表达相关的生物分子、脓毒症治疗靶点及脓毒症预后标志物。其中，该生物分子包括：如SEQ ID No.1所示的序列；或者如SEQ ID No.1所示的序列中的至少一个碱基发生变异，与SEQ ID No.1所示的序列具有作用于相同靶分子的变异序列；或者包含如SEQ ID No.1所示的序列或者其变异序列的RNA片段。该生物分子与Cx43的表达相关，参与到脓毒症的分子调控机制之中，能够作为脓毒症治疗靶点或者脓毒症的预后标志物使用。