Mosapride organic acid crystal

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a mosapride organic acid crystal and a preparation method thereof.The organic acid in the mosapride organic acid crystal is selected from oxalic acid or gallic acid, the mosapride organic acid crystal ha...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHENG JIAFANG, ZHAI LIHAI, WANG JUJU, XIA XIANGLAI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention belongs to the technical field of medicinal chemistry, and particularly relates to a mosapride organic acid crystal and a preparation method thereof.The organic acid in the mosapride organic acid crystal is selected from oxalic acid or gallic acid, the mosapride organic acid crystal has high solubility and good light stability, and the mosapride organic acid crystal can be used for preparing mosapride. The bioavailability can be improved, and the method has important value on optimization and development of mosapride preparations. 本发明属于药物化学技术领域,具体涉及莫沙必利有机酸晶体及其制备方法,本发明提供的莫沙必利有机酸晶体中有机酸选自草酸或没食子酸,本发明提供的莫沙必利有机酸晶体具有较高的溶解度和良好的光稳定性,有助于改善生物利用度,对莫沙必利制剂的优化和开发具有重要价值。