Preparation method and application of lidocaine hydrochloride

The invention discloses a lidocaine hydrochloride preparation method and application thereof.The lidocaine hydrochloride preparation method at least comprises the following steps that S1, lidocaine, purified water and acetone are mixed and heated, hydrogen chloride gas is introduced, the temperature is controlled, heat preservation stirring is conducted, lidocaine hydrochloride is added after cooling, cooling continues to be conducted after heat preservation stirring, centrifugation and drying are conducted after heat preservation stirring, and lidocaine hydrochloride is obtained; a lidocaine hydrochloride crude product is obtained; s2, refining the crude product obtained in the step S1 to obtain a lidocaine hydrochloride finished product. According to the present invention, the yield of the lidocaine hydrochloride prepared by using the raw materials according to the specific ratio and the process conditions is high, the obtained lidocaine hydrochloride crystal has characteristics of uniform size and no glome