Synthesis process of dipeptide-2

The invention relates to a synthesis process of dipeptide-2, which belongs to the field of biological medicine, and is characterized in that valine and triphosgene are used as raw materials to synthesize Val-NCA, and then the Val-NCA reacts with tryptophan under alkaline conditions to synthesize the...

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Bibliographische Detailangaben
Hauptverfasser: LI JIANGTAO, LIN ZHILE, YU GENGLI, ZHAO SHUAI, LIU CONG, LI KAIQING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a synthesis process of dipeptide-2, which belongs to the field of biological medicine, and is characterized in that valine and triphosgene are used as raw materials to synthesize Val-NCA, and then the Val-NCA reacts with tryptophan under alkaline conditions to synthesize the dipeptide-2; the qualified product can be obtained only through two-step reaction, the production period is greatly shortened, and the production cost is reduced. 本发明涉及一种二肽-2的合成工艺,属于生物医药领域,其特征在于,先以缬氨酸和三光气为原料合成Val-NCA,再与色氨酸在碱性条件下反应合成二肽-2;本发明仅通过两步反应就可以得到合格的产品,大幅度缩短了生产周期,降低了生产成本。