Disease-like antigen vaccine and preparation method thereof

The invention relates to a pathogen-like antigen (PLA) compound and a preparation method and application thereof, the pathogen-like antigen compound is composed of a structure-modified coliphage virus-like particle (VLP) and an antigen displayed on the VLP, and nucleic acid is wrapped in the virus-l...

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Bibliographische Detailangaben
Hauptverfasser:	HOU BAIDONG, HUA ZHAOLIN, GUO CHANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a pathogen-like antigen (PLA) compound and a preparation method and application thereof, the pathogen-like antigen compound is composed of a structure-modified coliphage virus-like particle (VLP) and an antigen displayed on the VLP, and nucleic acid is wrapped in the virus-like particle. The pathogen-like antigen complex formed by transformation effectively avoids aggregation or precipitation of virus-like particles, facilitates vaccine production, ensures stability of vaccine efficacy, and can effectively improve the immunogenicity of the vaccine without adding extra adjuvants. 本申请涉及一种病原样抗原(PLA)复合物及其制备方法和应用，该病原样抗原复合物由结构经改造的大肠杆菌噬菌体病毒样颗粒(VLP)及展示在其上的抗原构成，病毒样颗粒内部包裹有核酸。经改造形成的本发明的病原样抗原复合物有效避免了病毒样颗粒的聚集或沉淀，便利了疫苗的生产，确保疫苗效力的稳定，且无需额外添加佐剂就能有效提高疫苗的免疫原性。