Lipid compounds and liposomes comprising lipid compounds

The present invention relates to lipid analogs and liposomes comprising the same. Disclosed herein are polymer compounds having the general formula I: wherein m, n, X, Y, Z, and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIN WEIFENG, KLEIN JUERGEN, GOLDBERG RONIT
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The present invention relates to lipid analogs and liposomes comprising the same. Disclosed herein are polymer compounds having the general formula I: wherein m, n, X, Y, Z, and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the foregoing polymeric compound, as well as liposomes comprising such bilayers, and methods, uses, and compositions utilizing such bilayers and/or liposomes for reducing the coefficient of friction of a surface and/or for inhibiting biofilm formation. 本发明涉及脂质类似物和包含脂质类似物的脂质体。本文公开具有通式I的聚合物化合物:其中m、n、X、Y、Z和L如本文所定义。本文进一步公开包含至少一种形成双层的脂质和前述聚合物化合物的脂质双层,以及包含这种双层的脂质体,以及利用这种双层和/或脂质体用于降低表面的摩擦系数和/或用于抑制生物膜形成的方法、用途和组合物。