6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors

The present invention relates to 6-6 fused bicyclic heteroaryl compounds and uses thereof as LATS inhibitors, and more particularly, to 6-6 fused bicyclic heteroaryl compounds having a formula A2 or A1 and uses thereof as LATS inhibitors, or salts, stereoisomers or pharmaceutical compositions thereo...

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Hauptverfasser: PAN JING, LIU JUN, TERHOLZ JENS, XIE YUNFENG, YAN SHOUMENG, BERENSTEIN FRANK, LI CHONG, LIU YANG, QU, XIN, ZOU YEFEN, HOFFMANN THOMAS, LACOSTE ANA, HAO XUESHI, MO TAO, MAIBAUM JUERGEN KLAUS, JIN QIHUI, BEHNKE, DIRK
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to 6-6 fused bicyclic heteroaryl compounds and uses thereof as LATS inhibitors, and more particularly, to 6-6 fused bicyclic heteroaryl compounds having a formula A2 or A1 and uses thereof as LATS inhibitors, or salts, stereoisomers or pharmaceutical compositions thereof; wherein the variables are as defined herein (A1 amp; a2). The invention further relates to methods of inhibiting LATS in a population of cells using a compound of formula A1 or a salt, stereoisomer or pharmaceutical composition thereof. The invention further provides a method for preparing the compounds of the invention and its therapeutic use. The invention further provides methods for the preparation of the compounds of the invention, methods of medical use of the compounds of the invention, the use of the compounds of the invention in the treatment and management of diseases or disorders. 本发明涉及6-6稠合双环杂芳基化合物及其作为LATS抑制剂的用途,尤其涉及具有式A2或A1的6-6稠合双环杂芳基化合物及其作为LATS抑制剂的用途,或其盐、立体异构体或药物组合物;其中变量如本文中所定义(A1&A2)。本发明进一步涉及使用具有式