Tissue-engineered bone and preparation method thereof

The invention discloses a woven engineered bone and a preparation method thereof, and the method comprises the following steps: inoculating bone marrow mesenchymal stem cells on a scaffold carrier to enable the bone marrow mesenchymal stem cells to adhere and grow to obtain a tissue engineered bone...

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Bibliographische Detailangaben
Hauptverfasser: WU YUEHAO, HUANG XU, FANG XIN, ZHI WEI, WU JINJIE, WANG JIANXIN, ZHU XIUPENG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a woven engineered bone and a preparation method thereof, and the method comprises the following steps: inoculating bone marrow mesenchymal stem cells on a scaffold carrier to enable the bone marrow mesenchymal stem cells to adhere and grow to obtain a tissue engineered bone primary embryo; square wave and triangular wave electric signals are sequentially adopted to drive micro-vibration dynamic stimulation to act on the tissue-engineered bone primary embryo, so that the tissue-engineered bone with enhanced cell proliferation activity and osteogenic differentiation activity is obtained. According to the preparation method, mechanical stimulation generated by different electric signal waveforms is adopted to regulate and control the proliferation activity or osteogenic differentiation capacity of cells, square wave electric signal driving mechanical stimulation is adopted to improve the cell activity of the tissue-engineered bone, and then triangular wave electric signal driving mechani