Cell immunomodulatory protein and application thereof

The invention relates to the technical field of gene engineering, in particular to a cellular immunomodulatory protein and application thereof, the cellular immunomodulatory protein is pIL-18BP-X2, and the amino acid sequence of the pIL-18BP-X2 is as shown in SEQ ID NO.1. The invention further discl...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG JINLONG, DONG PENG, WANG FENGXUE, ZHAO HONGZHE, WEN YONGJUN, KANG BIN, ZHAO BINGWU, WU YUMEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the technical field of gene engineering, in particular to a cellular immunomodulatory protein and application thereof, the cellular immunomodulatory protein is pIL-18BP-X2, and the amino acid sequence of the pIL-18BP-X2 is as shown in SEQ ID NO.1. The invention further discloses a preparation method of the cellular immunomodulatory protein. The cellular immunomodulatory protein pIL-18BP-X2 obtained from porcine alveolar macrophages (PAM) can be efficiently expressed in an escherichia coli expression system, and a single protein can be obtained after NI column purification; the porcine interferon gamma protein has the effects of reducing the secretion of porcine interferon gamma (pIFN-gamma), remarkably inhibiting the mRNA expression quantity of the pIFN-gamma and regulating the activity of the pIFN-gamma, and has the treatment application potential. Therefore, the pIL-18BP-X2 protein disclosed by the invention enriches the cellular immunity regulator and provides good help for regulat