Quinoxaline derivative as well as preparation method and application thereof

Quinoxaline derivative as well as preparation method and application thereof

The invention relates to a quinoxaline derivative with a structure as shown in a formula (I), or a salt thereof, or a pharmaceutically acceptable carrier thereof. The quinoxaline compound has AXL and c-Met double-effect kinase inhibition activity, can play a better anti-tumor effect, and also has go...

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Bibliographische Detailangaben
Hauptverfasser: CHEN YI, ZHOU XIJIE, WANG SIMING, DENG LIANWU, WU JUNJIE, LIAO CHUNSHU, LI YUCHUAN, HUANG TONGKUN, ZHU DONGNING, CHEN BIN, LIU BING, MA BIN, LIU YIFEI, CAI HAN, HUANG DEXIAN, DONG JUNJUN, YIN CHENSEN
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a quinoxaline derivative with a structure as shown in a formula (I), or a salt thereof, or a pharmaceutically acceptable carrier thereof. The quinoxaline compound has AXL and c-Met double-effect kinase inhibition activity, can play a better anti-tumor effect, and also has good safety and tolerance at the same time. 本发明涉及一种具有如式(I)所示结构的喹喔啉类衍生物、或其盐、或其药学上可接受的载体。该喹喔啉类化合物具有AXL和c-Met双效激酶抑制活性，能够发挥较好的抗肿瘤功效，同时还具有良好的安全性和耐受性。