Infectious bursal disease virus recombinant VP2 protein and application thereof in vaccine

The invention provides a recombinant VP2 protein and a gene for coding the protein, after the recombinant VP2 protein and an adjuvant are emulsified, a prepared vaccine is high in safety, has a very good immune effect on both a bursa of Fabricius classical strain and a variant strain, is small in re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YUE FENGXIONG, SHEN HAOYUE, LI SANPENG, XIANG CONGYING, LIU HANPING, CHEN GUIHUA, LI GUANGHAO, LI GANG, ZHANG DONGDONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a recombinant VP2 protein and a gene for coding the protein, after the recombinant VP2 protein and an adjuvant are emulsified, a prepared vaccine is high in safety, has a very good immune effect on both a bursa of Fabricius classical strain and a variant strain, is small in required immune dosage, can effectively prevent infection of the bursa of Fabricius classical strain and the variant strain on chicken flocks, and has a good application prospect. The popularization and application values are realized. 本发明提供了一种重组VP2蛋白以及编码该蛋白的基因,本发明重组VP2蛋白与佐剂乳化后,制备的疫苗安全性高,对法氏囊经典株和变异毒株均具有很好的免疫效果,且所需免疫剂量小,能有效预防法氏囊经典株、变异株对鸡群的感染,具有推广应用价值。