5-hydroxy-3-methylpyridino [2, 3-d] pyrimidine compound as well as preparation and application thereof

The invention discloses a 5-hydroxy-3-methylpyrido [2, 3-d] pyrimidine compound as well as preparation and application thereof, belongs to the technical field of medicines, and particularly relates to a 3-methylpyrido [2, 3-d] pyrimidine-2, 4, 7 (1H, 3H, 8H)-triketone compound. The structural general formula of the compound is as shown in formula (I), wherein R1 is hydrogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, halogen-substituted C1-C4 alkoxy, halogen, nitryl, amino or C1-C4 alkylamino; r2 is hydrogen, a C1-C6 alkyl group, a C1-C4 alkyl substituted aryl group, a C1-C4 alkoxy group, a halogen substituted C1-C4 alkoxy group or a C1-C6 alkylamino group; r3 is hydrogen, a C1-C6 alkyl group, a C1-C6 alkylamino group, a phenyl group or a benzyl group substituted or unsubstituted by a C1-C4 alkyl group; the synthesis method of the compound is simple and convenient, the compound is suitable for industrial production, and biological activity tests show that the compound has anti-tumor activity