Preparation method of calcium folinate
The invention provides a preparation method of calcium folinate, which comprises the following steps: firstly, folic acid serving as a raw material is reduced to obtain a reduction product tetrahydrofolic acid, then the tetrahydrofolic acid is subjected to formylation reaction to obtain 5, 10-methyl...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention provides a preparation method of calcium folinate, which comprises the following steps: firstly, folic acid serving as a raw material is reduced to obtain a reduction product tetrahydrofolic acid, then the tetrahydrofolic acid is subjected to formylation reaction to obtain 5, 10-methylene tetrahydrofolic acid, the 5, 10-methylene tetrahydrofolic acid and hydrochloric acid are salified to obtain 5, 10-methylene tetrahydrofolic acid hydrochloride, and then the 5, 10-methylene tetrahydrofolic acid hydrochloride is added into the 5, 10-methylene tetrahydrofolic acid hydrochloride to obtain the calcium folinate. Hydrolyzing 1, 10-methylenetetrahydrofolic acid hydrochloride, and then generating calcium folinate with calcium salt; wherein in the process of obtaining the 5, 10-methylene tetrahydrofolic acid through formylation reaction of the tetrahydrofolic acid, methyl formate is added at low temperature to react with the tetrahydrofolic acid, then the temperature is increased, formic acid is added, a |
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