Immune cell capable of targeting antigen and simultaneously secreting CD47 antibody and application of immune cell

The invention discloses an immune cell capable of targeting an antigen and simultaneously secreting a CD47 antibody and application of the immune cell, belonging to the field of tumor immune cell therapy. On one hand, the invention provides the chimeric antigen receptor which is formed by sequentially connecting a first signal peptide, an antigen binding fragment, a hinge region, a transmembrane region, an intracellular costimulatory signal domain, an intracellular domain, a self-cleavage sequence, a second signal peptide and an anti-CD47 single-chain antibody in series; on the other hand, the invention provides an immune cell which targets an antigen and simultaneously exocrine a CD47 antibody, especially a T cell, an NK cell or an NKT cell modified by a chimeric antigen receptor. The first nucleic acid for coding the antigen binding fragment and the second nucleic acid for coding the anti-CD47 single-chain antibody are constructed on the same carrier, local delivery of the anti-CD47 antibody can be realized