SARS-CoV-2 virus B.1. 1.529 mutant strain DNA vaccine and application

The invention relates to the technical field of biology, and particularly provides an SARS-CoV-2 virus B.1. 1.529 mutant strain DNA (Deoxyribose Nucleic Acid) vaccine and application thereof. The SEQ ID NO: 1 sequence provided by the invention can be efficiently transcribed and expressed in a eukary...

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Hauptverfasser: ZHAO GAN, DING YUAN, ZHANG ZHIYU, HOU JIAWANG, YU QINGLING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of biology, and particularly provides an SARS-CoV-2 virus B.1. 1.529 mutant strain DNA (Deoxyribose Nucleic Acid) vaccine and application thereof. The SEQ ID NO: 1 sequence provided by the invention can be efficiently transcribed and expressed in a eukaryotic expression system, has immunogenicity, and is expressed in humoral immune and cellular immune response, and the nucleic acid vaccine taking the SEQ ID NO: 1 sequence as an active component also has good immunogenicity. 本发明涉及生物技术领域,具体而言,提供了一种SARS-CoV-2病毒B.1.1.529突变株DNA疫苗及应用。本发明提供的SEQ ID NO:1序列在真核表达系统中能够高效转录和表达,而且具有免疫原性,表现在体液免疫和细胞免疫应答,以此作为活性成分的核酸疫苗同样具有良好的免疫原性。