Linear head-tail diamine bridged compound and application thereof in preparation of medicine for treating glucose metabolism disorder disease

The invention discloses a linear head-tail diamine bridged compound, a preparation method thereof and an application of the linear head-tail diamine bridged compound in preparation of a medicine for treating a glucose metabolism disorder disease. The structure of the compound is as shown in a formula I which is described in the specification. The compound disclosed by the invention has obvious inhibitory activity on aldose reductase and has certain oxidation resistance. The application of the compound in preparation of drugs for treating glucose metabolism disorder diseases, drugs for treating diabetic complications and diseases caused by oxidative stress is reported for the first time. Compared with the prior art, the compound is novel in structure and simple in preparation process, and the curative effect of the compound is superior to that of a positive control drug epalrestat. 本发明公开了一种线性头尾二胺桥连化合物及其制法和在制备治疗糖代谢紊乱疾病的药物中的应用，该化合物的结构如式I所示。本发明的化合物对醛糖还原酶具有显著的抑制活性，并具有一定的抗氧化性。本发明的化合物在制备治疗糖代谢紊乱疾病的药物、治疗糖尿病并发症药物以及治疗由氧