Rapid separation type liposome composite sustained-release microneedle and preparation method thereof

The invention belongs to the technical field of microneedle drug delivery systems, and particularly relates to a rapid separation type lipidosome composite sustained-release microneedle and a preparation method thereof.The microneedle comprises a needle tip layer, a separation layer and a base layer, the separation layer is located between the needle tip layer and the base layer, lipidosome is dispersed in the needle tip layer, and the separation layer is located between the needle tip layer and the base layer. The needle point layer and the lipidosome of the needle point layer can carry drugs, and the drugs can be different drugs; the needle tip layer is prepared from glucan and chitosan; the liposome is prepared from phosphatidylcholine and cholesterol; the separation layer is prepared from a high-molecular polymer with a polar group and small-molecular sugar; the base layer is prepared from a high-molecular polymer material. The separated liposome composite microneedle has the advantages of good biocompati