Novel antibiotic release system as well as preparation method and application thereof

The invention relates to a novel antibiotic slow-release preparation method and application thereof. The novel antibiotic slow-release preparation method comprises a solid vancomycin nano-microsphere PLGA-PTMC slow-release system and a liquid BMSCs-PLGA-PTMAC stent. When infectious bone defects are...

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Bibliographische Detailangaben
Hauptverfasser:	ZHAO AIQING, GONG YULIN, BAI RUI, MENG CHENYANG, WANG WENXUAN, ZHAO ZHENQUN, WANG YONG, JIANG BOYONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a novel antibiotic slow-release preparation method and application thereof. The novel antibiotic slow-release preparation method comprises a solid vancomycin nano-microsphere PLGA-PTMC slow-release system and a liquid BMSCs-PLGA-PTMAC stent. When infectious bone defects are treated, compared with a vancomycin CPC sustained-release system implantation group, the anti-infection ability of the CPC sustained-release system group containing vancomycin and BMSCs is stronger when the CPC sustained-release system group containing vancomycin and BMSCs is implanted. When infectious bone defects are treated, compared with a vancomycin CPC sustained-release system implantation group, the bone formation capability of the CPC sustained-release system group containing vancomycin and BMSCs is higher. In the treatment of infectious bone defects, the absorbability of the CPC slow release system containing vancomycin and BMSCs is good. The local application of the CPC sustained release system containing