Method for purifying monoclonal antibodies
A method for purifying a liquid feedstock comprising monoclonal antibodies and impurities, said method comprising passing said liquid feedstock through an instrument comprising at least two processing units, each such unit producing a product stream comprising purified monoclonal antibodies and opti...
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| creator | PREHN JANINE HESS CHRISTOPHER NAGY TIBOR HAIGH JONATHAN TOPPING ANDREW |
| description | A method for purifying a liquid feedstock comprising monoclonal antibodies and impurities, said method comprising passing said liquid feedstock through an instrument comprising at least two processing units, each such unit producing a product stream comprising purified monoclonal antibodies and optionally a waste stream comprising at least some of said impurities, wherein each unit comprises prescribed components (i) to (v) comprising a multi-inlet flow controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One unit performs chromatography and the other performs virus inactivation. In addition to the devices that they contain, the units may be substantially identical, resulting in advantages in simplicity, cost and ease of operation, lower risk of operator errors, easier maintenance, and lower inventory of spare parts.
用于纯化包含单克隆抗体和杂质的液体原料的方法，所述方法包括使所述液体原料通过包含至少两个加工单元的仪器，每个这样的单元生产含有纯化的单克隆抗体的产物流和任选的包含至少一 |
| format | Patent |
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用于纯化包含单克隆抗体和杂质的液体原料的方法，所述方法包括使所述液体原料通过包含至少两个加工单元的仪器，每个这样的单元生产含有纯化的单克隆抗体的产物流和任选的包含至少一</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SEPARATION ; SPIRITS ; TESTING ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220527&DB=EPODOC&CC=CN&NR=114555794A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220527&DB=EPODOC&CC=CN&NR=114555794A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PREHN JANINE</creatorcontrib><creatorcontrib>HESS CHRISTOPHER</creatorcontrib><creatorcontrib>NAGY TIBOR</creatorcontrib><creatorcontrib>HAIGH JONATHAN</creatorcontrib><creatorcontrib>TOPPING ANDREW</creatorcontrib><title>Method for purifying monoclonal antibodies</title><description>A method for purifying a liquid feedstock comprising monoclonal antibodies and impurities, said method comprising passing said liquid feedstock through an instrument comprising at least two processing units, each such unit producing a product stream comprising purified monoclonal antibodies and optionally a waste stream comprising at least some of said impurities, wherein each unit comprises prescribed components (i) to (v) comprising a multi-inlet flow controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One unit performs chromatography and the other performs virus inactivation. In addition to the devices that they contain, the units may be substantially identical, resulting in advantages in simplicity, cost and ease of operation, lower risk of operator errors, easier maintenance, and lower inventory of spare parts.
用于纯化包含单克隆抗体和杂质的液体原料的方法，所述方法包括使所述液体原料通过包含至少两个加工单元的仪器，每个这样的单元生产含有纯化的单克隆抗体的产物流和任选的包含至少一</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SEPARATION</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDyTS3JyE9RSMsvUigoLcpMq8zMS1fIzc_LT87Jz0vMUUjMK8lMyk_JTC3mYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhiampqbmliaOxsSoAQBYoil8</recordid><startdate>20220527</startdate><enddate>20220527</enddate><creator>PREHN JANINE</creator><creator>HESS CHRISTOPHER</creator><creator>NAGY TIBOR</creator><creator>HAIGH JONATHAN</creator><creator>TOPPING ANDREW</creator><scope>EVB</scope></search><sort><creationdate>20220527</creationdate><title>Method for purifying monoclonal antibodies</title><author>PREHN JANINE ; HESS CHRISTOPHER ; NAGY TIBOR ; HAIGH JONATHAN ; TOPPING ANDREW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114555794A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SEPARATION</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PREHN JANINE</creatorcontrib><creatorcontrib>HESS CHRISTOPHER</creatorcontrib><creatorcontrib>NAGY TIBOR</creatorcontrib><creatorcontrib>HAIGH JONATHAN</creatorcontrib><creatorcontrib>TOPPING ANDREW</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PREHN JANINE</au><au>HESS CHRISTOPHER</au><au>NAGY TIBOR</au><au>HAIGH JONATHAN</au><au>TOPPING ANDREW</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for purifying monoclonal antibodies</title><date>2022-05-27</date><risdate>2022</risdate><abstract>A method for purifying a liquid feedstock comprising monoclonal antibodies and impurities, said method comprising passing said liquid feedstock through an instrument comprising at least two processing units, each such unit producing a product stream comprising purified monoclonal antibodies and optionally a waste stream comprising at least some of said impurities, wherein each unit comprises prescribed components (i) to (v) comprising a multi-inlet flow controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One unit performs chromatography and the other performs virus inactivation. In addition to the devices that they contain, the units may be substantially identical, resulting in advantages in simplicity, cost and ease of operation, lower risk of operator errors, easier maintenance, and lower inventory of spare parts.
用于纯化包含单克隆抗体和杂质的液体原料的方法，所述方法包括使所述液体原料通过包含至少两个加工单元的仪器，每个这样的单元生产含有纯化的单克隆抗体的产物流和任选的包含至少一</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SEPARATION SPIRITS TESTING TRANSPORTING VINEGAR WINE |
| title | Method for purifying monoclonal antibodies |
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