4-substituted indole and indazole sulfonamide derivatives as PARG inhibitors

The present invention provides a compound represented by the following formula: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, Ar, X1, X2 and ring B have the definitions given below. The compounds provided are potent inhibitors of poly ADP-ribose glycohydrolase (PARG). 本发明提供了一种下式所示的化合物：或其药学上可接受的盐，其中，R1、R2、R3、R4、R5、R6、R7、Ar、X1、X2和环B具有下文中给出的定义。所提供的化合物是有效的聚ADP-核糖糖水解酶(PARG)抑制剂。