Therapeutic compositions and methods for treating cancer in combination with analogs of interleukin protein

Therapeutic compositions and methods for treating cancer in combination with analogs of interleukin protein

Compositions and methods are provided for treating cancer by administering an anti-CD47 mAb and an anti-CD47 fusion protein having different functional characteristics or a combination of an immune effector cell carrying a chimeric antigen receptor (CAR) and an analog of an interleukin protein. 提供了用...

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Hauptverfasser: PURO ROBYN, RICHARDS JOHN, MCCANN JAMES, STROHL WILLIAM, PEREIRA DANIEL, MONAHAN JOHN, ALMAGRO, JUAN, BOHLING JAMES
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compositions and methods are provided for treating cancer by administering an anti-CD47 mAb and an anti-CD47 fusion protein having different functional characteristics or a combination of an immune effector cell carrying a chimeric antigen receptor (CAR) and an analog of an interleukin protein. 提供了用于通过施用具有不同功能特征的抗CD47 mAb和抗CD47融合蛋白或携带嵌合抗原受体(CAR)的免疫效应细胞与白介素蛋白的类似物的组合来治疗癌症的组合物和方法。