Anti-FLT-1 antibodies for treatment of duchenne muscular dystrophy

The present invention provides, inter alia, anti-Flt-1 antibodies and methods for the treatment of muscular dystrophy, in particular Duchenne muscular dystrophy (DMD). In some embodiments, a method according to the invention comprises administering to an individual suffering from or susceptible to DMD an effective amount of an anti-Flt-1 antibody or antigen binding protein thereof such that at least one symptom or feature of DMD is reduced in intensity, severity, or frequency or delayed onset. 本发明尤其提供用于治疗肌营养不良、具体地说杜氏肌营养不良(DMD)的抗Flt-1抗体和方法。在一些实施方案中，根据本发明的方法包括向患有或易患DMD的个体施用有效量的抗Flt-1抗体或其抗原结合蛋白，以使得DMD的至少一种症状或特征在强度、严重程度或频率方面降低或延迟发作。