Lipid nanoparticles and use thereof in nucleic acid delivery

The invention discloses lipid nanoparticles and application thereof in nucleic acid delivery. The functional lipid provided by the invention takes tertiary amine or a PEG fragment as a hydrophilic part, amino acid as a skeleton, an ester bond as a connecting bond and an alkane chain as a hydrophobic part, and has the advantages of good biocompatibility, high safety, simple and rapid synthesis method and the like. The lipid nanoparticles prepared based on the functional lipid designed by the invention can stably load nucleic acid drugs, and the transfection effect on primary cells and tumor cells is remarkable. The invention provides a novel lipid material capable of effectively transfecting cells, and provides a safe and effective non-viral vector platform for cell transfection. 本发明公开了脂质纳米粒及其在核酸递送中的应用。本发明的功能脂质以叔胺或PEG片段作为亲水部分，以氨基酸作为骨架，以酯键作为连接键，以烷烃链作为疏水部分，具有生物相容性好、安全性高、合成方法简便快捷等优势。基于本发明设计的功能脂质制备的脂质纳米粒能稳定荷载核酸药物，且在原代细胞和肿瘤细胞上转染效果显著。本发明将提供一类能够有效转染细胞的新型脂质材料，并为细胞转染提供安全有效的非病毒载体平台。