一种原位生长纤维形二氧化硅纳米粒子毛细管开管柱及其制备方法

本发明属于分析化学技术领域，公开了一种原位生长纤维形二氧化硅纳米粒子毛细管开管柱及其制备方法。该制备方法将预处理后的毛细管一端置于反应液中，另一端置于水中，在保护气体驱动和加热条件下，在毛细管内壁修饰纤维形二氧化硅纳米粒子。其中，毛细管的内径小于10μm。本发明通过在窄内径毛细管内壁修饰二氧化硅纳米粒子，可增加柱内比表面积，相对于裸毛细管能够增多被分析物与管内壁的相互作用位点，且该方法制备的毛细管开管柱的涂层与内壁结合稳定、柱间重复性好、分离能力强，为超微量样品的分析提供了研究手段。 The invention belongs to the technical field of analytical chemistry, and discloses an in-situ growth fibrous silicon dioxide nanoparticle capillary open tubular column and a preparation method thereof. According to the preparation method, one end of a pretreated capillary tube is placed in a reaction solution, the other end of the pretreated capillary tube is placed in water, and the inner wall of the capillary tube is modified with fiber-shaped silicon dioxide nanoparticles under the driving and heating conditions of protective gas. Wherein the inner diameter of the capillary tube is smaller than 10 microns. The silicon dioxide nanoparticles are modified on the inner wall of the narrow-inner-diameter capillary tube, so that the specific surface area in the column can