Preparation method and application of endothelialization promoting choked flow membrane

The invention provides a preparation method and application of a choked flow membrane for promoting endothelialization, and the method comprises the following steps: extracting and purifying sericin; carrying out surface treatment on the choked flow film; sericin is grafted on the surface of the choked flow membrane; and immobilizing the bioactive molecules. According to the invention, the flow blocking membrane is subjected to surface treatment, sericin molecules are grafted to the flow blocking membrane through a Schiff base reaction or a self-assembly method, and biomolecules for promoting endothelialization are fixed on the surface of the flow blocking membrane through the Schiff base reaction, so that in-situ endothelialization promotion is realized, and the speed of endothelialization on the surface of the heart occluder is increased; the choked flow membrane prepared by the method provided by the invention has higher hardness, can promote endothelialization, and potentially prolongs the service life of