Polypeptide sequence of KDM6B and application of KDM6B in regulating and controlling functions of mesenchymal stem cells
The invention relates to the field of biomedicine, in particular to application of KDM6B to regulation and control of functions of mesenchymal stem cells. And the WDR5 is a co-binding protein for negatively regulating and controlling the functions of the histone demethylase KDM6B and the MLL1. The W...
Gespeichert in:
Hauptverfasser: | , , , , |
---|---|
Format: | Patent |
Sprache: | chi ; eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The invention relates to the field of biomedicine, in particular to application of KDM6B to regulation and control of functions of mesenchymal stem cells. And the WDR5 is a co-binding protein for negatively regulating and controlling the functions of the histone demethylase KDM6B and the MLL1. The WDR5 can form a protein complex with histone demethylase KDM6B to inhibit the function of the KDM6B, so that expression and functions of genes are regulated and controlled by regulating and controlling the methylation state of downstream senescence and osteogenesis related genes and gene promoter region histone, and finally the effects of regulating stem cell senescence and differentiation functions and bone/tooth tissue repair and regeneration functions are achieved. Aiming at a KDM6B and WDR5 binding region sequence, small-molecule polypeptide is researched, developed and utilized, and the function of the mesenchymal stem cell is regulated by regulating and controlling the binding of a KDM6B/WDR5 complex. Finally, |
---|