Method for preparing functionalized methyl 2-(3-oxoisoindoline-1-subunit) acetate from carbon dioxide

The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for preparing functionalized 2-(3-oxoisoindoline-1-subunit) methyl acetate from carbon dioxide. The method comprises the following steps: by taking o-alkynyl amide and carbon dioxide as raw materials and N, N-dimethylformamide as a solvent, reacting in an oil bath pan at 60 DEG C for 12 hours under the promotion of alkali, and then adding methyl iodide to continuously react for 1 hour to obtain a product. And a series of functionalized 2-(3-oxoisoindoline-1-subunit) methyl acetate compounds with high yield can be obtained by simply post-treating the reaction product. The o-alkynyl amides containing different substituent groups can be used as reaction substrates to obtain the corresponding 2-(3-oxoisoindoline-1-subunit) methyl acetate compound. 本发明涉及医药、有机化工及精细化工领域，具体涉及一种由二氧化碳制备官能团化2-(3-氧代异吲哚啉-1-亚基)乙酸甲酯的方法。以邻炔基酰胺和二氧化碳为原料，在碱促进下，N,N-二甲基甲酰胺做溶剂，在60℃油浴锅中反应12小时，接着再加入碘甲烷继续反应1小时得到产物。反应后的产物经过简