Pleuromutilin alpha-cyano cinnamate compound with drug-resistant bacterium resisting activity as well as preparation method and application of pleuromutilin alpha-cyano cinnamate compound

The invention discloses pleuromutilin alpha-cyano cinnamate compounds with drug-resistant bacterium resisting activity as well as a preparation method and application of the pleuromutilin alpha-cyano cinnamate compounds, and belongs to the technical field of medical chemistry. The method comprises the following steps: firstly, preparing benzaldehyde compounds containing different substituent groups into corresponding alpha-cyano cinnamic acid, and then dissolving the alpha-cyano cinnamic acid containing different substituent groups and pleuromutilin in an organic solvent or ionic liquid to react, thereby synthesizing the pleuromutilin alpha-cyano cinnamate compounds which are not reported. The synthesis method is mature, simple in reaction condition, high in reaction yield and suitable for industrial production. An in-vitro antibacterial experiment shows that the pleuromutilin alpha-cyano cinnamate compound synthesized by the preparation method disclosed by the invention has relatively strong antibacterial ac