Medicine for treating doxorubicin-induced cardiotoxic injury and application

The invention provides a medicine for treating doxorubicin-induced cardiotoxic injury and application, and relates to the technical field of biological medicine. The invention provides application of a reagent for interfering expression of circular RNAcirc-ZNF609 in myocardial tissue in preparation...

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Bibliographische Detailangaben
Hauptverfasser:	XIAO JUNJIE, WANG LIJUN, SHEN KETING, QI WEITONG, ZHU LIYUN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a medicine for treating doxorubicin-induced cardiotoxic injury and application, and relates to the technical field of biological medicine. The invention provides application of a reagent for interfering expression of circular RNAcirc-ZNF609 in myocardial tissue in preparation of a medicine for preventing and/or treating doxorubicin-induced cardiotoxic injury, the reagent or the medicine can deliver a gene sequence of circ-ZNF609shRNA which is artificially designed into the myocardial tissue based on AAV virus, and the reagent or the medicine can be used for preparing a medicine for preventing and/or treating doxorubicin-induced cardiotoxic injury. The application has the effects of inhibiting apoptosis of myocardial cells, improving the systolic function of the heart and resisting doxorubicin-induced cardiac toxic injury by inhibiting apoptosis of the circular RNAcirc-ZNF609 in myocardial tissues and interfering expression of the circular RNAcirc-ZNF609 in the myocardial tissues. 本发明提供了