Application of Lgmn as target spot in treatment of ischemic heart disease

The invention discloses application of Lgmn as a target spot in treatment of ischemic heart disease. Through technical means of gene chip, differential gene analysis, in-vitro cell phagocytic function detection, three-color immunofluorescence analysis and the like, specific high expression of Lgmn in heart in-situ macrophages is found, mice are conditionally knocked out by using the Lgmn macrophages, the effect of the heart in-situ macrophage phagocytic function in myocardial infarction is disclosed, and the application of the Lgmn in myocardial infarction is promoted. The molecular mechanism of Lgmn for regulating myocardial cell apoptosis and inflammation regression is clarified, the action mechanism of immunoregulation of myocardial infarction is enriched, and a new therapeutic target is provided for clinical immunotherapy of myocardial infarction. The Lgmn adenovirus is injected into a mouse with myocardial infarction, so that necrotic and apoptotic myocardial cells can be quickly cleared, excessive and c