2-((2-methoxyphenyl) sulfonyl) isoindoline compound pharmaceutical preparation and preparation method thereof

The invention relates to the technical field of medicines, and provides a 2-((2-methoxyphenyl) sulfonyl) isoindoline compound pharmaceutical preparation and a preparation method thereof, and the 2-((2-methoxyphenyl) sulfonyl) isoindoline compound pharmaceutical preparation comprises a 2-((2-methoxyp...

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Bibliographische Detailangaben
Hauptverfasser: SHENG YINGJUAN, LIU LIYUAN, HUO ZHIQIANG, TIAN RUIQIONG, GUO TINGTING, TAN LIHE, DAI XINMIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of medicines, and provides a 2-((2-methoxyphenyl) sulfonyl) isoindoline compound pharmaceutical preparation and a preparation method thereof, and the 2-((2-methoxyphenyl) sulfonyl) isoindoline compound pharmaceutical preparation comprises a 2-((2-methoxyphenyl) sulfonyl) isoindoline compound or a pharmaceutically acceptable salt thereof, a filler, a disintegrating agent, an adhesive and a lubricant. The 2-((2-methoxyphenyl) sulfonyl) isoindoline compound has a structure as shown in a formula I, wherein R1 is methoxy, fluorine, chlorine, bromine, cyano, aminocarbonyl, acetyl, dimethylamino and trifluoromethyl, and R2 is 1H-indazole-5-group and 1H-pyrazole-4-group. The 2-((2-methoxyphenyl) sulfonyl) isoindoline compound pharmaceutical preparation can be used as an effective ROCK inhibitor, has high inhibitory activity, and has good pharmacological activity for treating tumors, cardiovascular diseases, nervous system diseases and fibrosis diseases. The 2-((2-methoxyph