Industrial preparation process of beta-nicotinamide mononucleotide

The invention relates to the technical field of chemical synthesis, in particular to an industrial preparation process of beta-nicotinamide mononucleotide, which comprises the following steps: (1) silanization; (2) condensation; (3) deacetylation; (4) phosphorylation; and (5) purifying and crystallizing. The preparation process has the advantages of simplicity in operation, easiness in amplification, good quality and the like, and strong acid type ion exchange resin is adopted as a catalyst in the phosphorylation process, so that the use of phosphorus oxychloride with strong irritation is avoided, the production operation is safer and more environment-friendly, and industrial amplification and production are facilitated. 本发明涉及化学合成技术领域，尤其是一种β-烟酰胺单核苷酸的工业化制备工艺，包括以下步骤：(1)硅烷化；(2)缩合；(3)脱乙酰；(4)磷酸化；(5)纯化结晶。本发明制备工艺具有操作简单、易放大、品质好等优点，而且磷酸化过程采用强酸型离子交换树脂作为催化剂，避免了使用强刺激性的三氯氧磷，使生产操作更安全更环保，更利于工业化放大和生产。