Application of curcumin in preparation of medicine for treating tumor with high expression of ARL8A and/or ARL8B protein

The invention belongs to the technical field of biological medicines, and particularly relates to application of a natural small molecule compound curcumin in preparation of a medicine for treating ARL8A and/or ARL8B protein high expression tumors, and the main content of the invention is that the c...

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Hauptverfasser: ZHAO XIAOHONG, REN JIXIA, WANG YANG, WU CHONGMING, XU SAIJUN, XIE YONG, CHENG ZHONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of biological medicines, and particularly relates to application of a natural small molecule compound curcumin in preparation of a medicine for treating ARL8A and/or ARL8B protein high expression tumors, and the main content of the invention is that the curcumin shows significant difference in cytotoxicity to different tumor cells. The intensity of the cytotoxicity is in positive correlation with the total expression quantity of two proteins, namely ARL8A and ARL8B, in cells; the lethal effect of the curcumin on the tumor cells with the total amount of the ARL8A and the ARL8B being high expression types is that the curcumin causes the cells to be in a long-term starvation state to induce autophagic death of the cells, and the application of the curcumin as an anti-tumor drug and the feasibility of the curcumin for treating a certain tumor can be pre-judged by detecting the expression quantities of the ARL8A and the ARL8B. 本发明属于生物医药技术领域,具体涉及天然小分子化合物姜黄素在制备治疗ARL8A和/或A