Vitamin C sustained-release pellet and preparation method thereof

The invention relates to a vitamin C sustained-release pellet and a preparation method thereof, and belongs to the field of vitamin C sustained-release preparations. The vitamin C sustained-release pellet is composed of a drug-loaded pellet core and a coating; the preparation method of the vitamin C...

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Bibliographische Detailangaben
Hauptverfasser: LI SUYING, TAO WEINA, ZHANG CAIYUN, YANG LANLIN, ZHAO XIAOPEI, ZHANG QIAN, TANG CHUNHUI, ZHOU XIAOLIN, ZHOU WENJIE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a vitamin C sustained-release pellet and a preparation method thereof, and belongs to the field of vitamin C sustained-release preparations. The vitamin C sustained-release pellet is composed of a drug-loaded pellet core and a coating; the preparation method of the vitamin C sustained-release pellet comprises two steps of preparation of a drug-loaded pellet core and coating. When the obtained vitamin C sustained-release pellets are used for 1 hour, 5 hours, 9 hours, 13 hours, 17 hours, 21 hours and 25 hours, the average accumulative release amount of the vitamin C in artificial gastric juice is 10.4 to 12.2 percent, 13.8 to 14.7 percent, 17.9 to 19.5 percent, 25.7 to 27.7 percent, 39.1 to 42.8 percent, 55.8 to 59.9 percent and 68.9 to 71.4 percent respectively; in the artificial intestinal juice, the contents of the components are respectively 9.2% to 10.4%, 11.4% to 13.6%, 15.3% to 17.3%, 23.9% to 28.4%, 37.3% to 40.6%, 44.7% to 48.2% and 59.2% to 64.9%. 一种维生素C缓释微丸及其制备方法,属于维生素C缓释制剂领域