UPA inhibitor as well as preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry. Specifically, the invention provides a compound with a benzo [d] [1, 3] dioxopentene-5-formamide structure and a preparation method thereof, and provides application of the compound in preparation of medicines for preventing or treating diseases caused by a urokinase plasminogen activator, so that the compound can be applied to important processes related to cell invasion and tissue remodeling. And a new way is provided for wound repair, bone remodeling, angiogenesis, tumor invasion and prevention and treatment of transfer and diffusion of focuses. 本发明属于药物化学技术领域。具体的，本发明提供了一种具有苯并[d][1,3]二氧戊烯-5-甲酰胺结构的化合物及其制备方法，并提供了上述化合物在制备预防或治疗由尿激酶纤溶酶原激活剂所带来的病症上的应用，从而为涉及细胞侵入和组织再造型的重要过程，包括伤口的修复、骨再造型、血管生成、肿瘤侵袭以及病灶的转移和扩散的预防和治疗提供新的途径。