Preparation method of 2-acetamido-5-chloropyridine
The invention relates to a preparation method of 2-acetamido-5-chloropyridine, which comprises the following steps: 1) dissolving 2-amino-5-chloropyridine in a solvent, adding organic alkali, slowly adding acetyl chloride, reacting until raw materials disappear, pouring reaction liquid into water, e...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention relates to a preparation method of 2-acetamido-5-chloropyridine, which comprises the following steps: 1) dissolving 2-amino-5-chloropyridine in a solvent, adding organic alkali, slowly adding acetyl chloride, reacting until raw materials disappear, pouring reaction liquid into water, extracting with dichloromethane, and drying to obtain a crude product; and 2) carrying out silica gel column chromatography on the crude product to obtain the 2-acetamido-5-chloropyridine.
本发明涉及一种2-乙酰氨基-5-氯吡啶的制备方法，所述方法包括以下步骤：1)将2-氨基-5-氯吡啶溶解于溶剂中，加入有机碱，后缓慢加入乙酰氯，反应至原料消失后，将反应液倒入水中，用二氯甲烷萃取，干燥得粗品；2)粗品经硅胶柱层析后，得到2-乙酰氨基-5-氯吡啶。 |
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