System and method for performing motion-insensitive resting three-dimensional magnetic resonance imaging

The invention relates to a system and method for performing motion-insensitive resting three-dimensional magnetic resonance imaging. A method for generating a motion-corrected medical image includes obtaining, via a processor, k-spatial data of a region of interest acquired by a magnetic resonance imaging system using a 3D radial pulse sequence with ZTE acquisition, the pulse sequence including optional magnetization preparation pulses. The method also includes sampling, via the processor, the k-space data to obtain a plurality of interleaved k-space segments. The method also includes reconstructing, via the processor, one or more of the plurality of interleaved k-space segments to generate a respective motion navigator volume. The method even further includes co-registering, via a processor, each respective motion navigator volume to estimate motion, and performing motion correction on the one or more interleaved k-space segments and their corresponding k-space trajectories. The method also includes generati