Preparation method of cycleanine

The invention provides a preparation method of cycleanine, and belongs to the field of organic synthesis. The invention provides a preparation method of cycleanine, which comprises the following reaction steps: a 1, 4, 7, 10-tetraazacyclododecane derivative is contacted with a carbonyl reducing agent to obtain cycleanine, the 1, 4, 7, 10-tetraazacyclododecane derivative is a compound with at least one carbon atom on the ring of 1, 4, 7, 10-tetraazacyclododecane being oxo, and the carbonyl reducing agent is a compound with at least one carbon atom on the ring of 1, 4, 7, 10-tetraazacyclododecane being oxo. The carbonyl reducing agent is lithium aluminum hydride, sodium borohydride or potassium borohydride. According to the technical scheme, the invention provides a brand-new cycleanine synthesis route which does not involve a ring-closing reaction and has high yield. 本发明提供了一种轮环藤宁的制备方法，属于有机合成领域。本发明提供了一种轮环藤宁的制备方法，包括如下反应步骤：将1,4,7,10-四氮杂环十二烷衍生物与羰基还原剂接触，得到轮环藤宁，其中，1,4,7,10-四氮杂环十二烷衍生物为1,4,7,10-四氮杂环十二烷的环上至少一个碳原子被氧代的化合