2-trifluoromethyl-4-aminoquinazoline compound and application thereof

The invention discloses a 2-trifluoromethyl-4-aminoquinazoline compound and application thereof, and the compound has a structural formula as shown in the following general formula I. According to the invention, trifluoromethyl is introduced to a 2-site of a 4-aminoquinazoline compound, and 4-amino is modified, so that the 2-trifluoromethyl-4-aminoquinazoline compound is obtained. A series of 2-trifluoromethyl-4-aminoquinazoline derivatives with novel structures are designed and synthesized by taking 2-trifluoromethyl-4-aminoquinazoline as a raw material, the probability of interaction between the compound and a target is increased, the biological activity and chemical stability of the compound are improved, and the druggability of the compound is improved, so that the 2-trifluoromethyl-4-aminoquinazoline compound has efficient and broad-spectrum anti-tumor activity. 本发明公开了一种2-三氟甲基-4-氨基喹唑啉类化合物及其应用，该化合物具有如下通式I所示的结构式：本发明将三氟甲基引入到4-氨基喹唑啉化合物的2-位，对4-氨基进行修饰，设计合成系列结构新颖的2-三氟甲基-4-氨基喹唑啉类衍生物，增加化合物与靶标之间相互作用的几率，提高化合物的生物活性、