N-substituted fluorine-containing pyrrolidine derivative as well as preparation method and application thereof

The invention provides an N-substituted fluorine-containing pyrrolidine derivative as shown in a structural formula I as well as a preparation method and application of the N-substituted fluorine-containing pyrrolidine derivative. Preliminary pharmacological activity screening shows that the compounds have an inhibiting effect on trichophyton rubrum, trichophyton mentagrophytes and candida albicans, and can be used for preparing medicines for treating diseases caused by fungi (such as tinea manuum, tinea pedis, tinea capitis, tinea corporis and onychomycosis caused by trichophyton rubrum and trichophyton mentagrophytes); ) and a medicine for progressive infection which may threaten life in immunodeficiency patients. The medicine can be used for preventing and treating infectious diseases caused by Candida albicans and immunodeficiency patients. 本发明提供了如结构式I所示的含N-取代含氟吡咯烷衍生物及其制备方法和用途。初步的药理活性筛选表明，这些化合物红色毛癣菌、须癣毛癣菌和白色念珠菌具有抑制作用，可用于制备治疗由真菌引起的疾病(比如红色毛癣菌、须癣毛癣菌引发的手癣、足癣、头癣，体癣和灰指甲等疾病；白色念珠菌引起的侵袭性感染疾病)和免疫缺陷患者中进行性的、可能威胁生命的感染