Method for carrying out Mitsunobu reaction on alcoholic hydroxyl group donor and active hydrogen donor

Method for carrying out Mitsunobu reaction on alcoholic hydroxyl group donor and active hydrogen donor

The invention provides a method for carrying out a Mitsunobu reaction on an alcoholic hydroxyl group donor and an active hydrogen donor. The method specifically comprises the following steps: carrying out a reaction on the alcoholic hydroxyl group donor, the active hydrogen donor, a trialkylphosphin...

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Hauptverfasser: ZHAO LILIANG, XU SHUANG, YE SHOUCHEN, SONG XIAOLONG
Format: Patent
Sprache:chi ; eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator ZHAO LILIANG
XU SHUANG
YE SHOUCHEN
SONG XIAOLONG
description The invention provides a method for carrying out a Mitsunobu reaction on an alcoholic hydroxyl group donor and an active hydrogen donor. The method specifically comprises the following steps: carrying out a reaction on the alcoholic hydroxyl group donor, the active hydrogen donor, a trialkylphosphine reagent and an azodicarboxylate reagent in the presence of an organic solvent, wherein the organic solvent is straight-chain or branched-chain alkane containing 8 to 16 carbon atoms. The method provided by the invention can solve the problems of difficult removal of by-products, high amount of post-treatment three wastes, low product purity and the like in the Mitsunobu reaction in the prior art, can effectively reduce the generation of dicarboxylic acid hydrazine by-products, can separate the target product from the reaction system more easily, and has the advantages of high reaction yield, convenient post-treatment, high product purity, no influence on subsequent application, and wide application prospect. And
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The method specifically comprises the following steps: carrying out a reaction on the alcoholic hydroxyl group donor, the active hydrogen donor, a trialkylphosphine reagent and an azodicarboxylate reagent in the presence of an organic solvent, wherein the organic solvent is straight-chain or branched-chain alkane containing 8 to 16 carbon atoms. The method provided by the invention can solve the problems of difficult removal of by-products, high amount of post-treatment three wastes, low product purity and the like in the Mitsunobu reaction in the prior art, can effectively reduce the generation of dicarboxylic acid hydrazine by-products, can separate the target product from the reaction system more easily, and has the advantages of high reaction yield, convenient post-treatment, high product purity, no influence on subsequent application, and wide application prospect. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Method for carrying out Mitsunobu reaction on alcoholic hydroxyl group donor and active hydrogen donor
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