Method for carrying out Mitsunobu reaction on alcoholic hydroxyl group donor and active hydrogen donor

The invention provides a method for carrying out a Mitsunobu reaction on an alcoholic hydroxyl group donor and an active hydrogen donor. The method specifically comprises the following steps: carrying out a reaction on the alcoholic hydroxyl group donor, the active hydrogen donor, a trialkylphosphine reagent and an azodicarboxylate reagent in the presence of an organic solvent, wherein the organic solvent is straight-chain or branched-chain alkane containing 8 to 16 carbon atoms. The method provided by the invention can solve the problems of difficult removal of by-products, high amount of post-treatment three wastes, low product purity and the like in the Mitsunobu reaction in the prior art, can effectively reduce the generation of dicarboxylic acid hydrazine by-products, can separate the target product from the reaction system more easily, and has the advantages of high reaction yield, convenient post-treatment, high product purity, no influence on subsequent application, and wide application prospect. And