Method for detecting triethylamine and N, N-diethylaniline in ceftazidime and application
The invention discloses a method for detecting triethylamine and N, N-diethylaniline in ceftazidime and application of the method. The detection method disclosed by the invention comprises the following steps: injecting a test solution containing ceftazidime into a gas chromatograph in a direct samp...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for detecting triethylamine and N, N-diethylaniline in ceftazidime and application of the method. The detection method disclosed by the invention comprises the following steps: injecting a test solution containing ceftazidime into a gas chromatograph in a direct sample injection manner, recording a chromatogram, and calculating the content according to an external standard method; wherein the detection conditions of the chromatography are as follows: a chromatographic column is a capillary column taking modified dimethyl polysiloxane as a stationary liquid or a capillary chromatographic column with equivalent efficiency; the initial temperature is 95-105 DEG C, the temperature is maintained for 3 minutes, the temperature is raised to 220 DEG C at the rate of 10 DEG C per minute, and the temperature is maintained for 10 minutes. The method has good specificity and system adaptability, extremely low detection limit and quantitation limit, good linearity and good accuracy.
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