Method for detecting triethylamine and N, N-diethylaniline in ceftazidime and application

The invention discloses a method for detecting triethylamine and N, N-diethylaniline in ceftazidime and application of the method. The detection method disclosed by the invention comprises the following steps: injecting a test solution containing ceftazidime into a gas chromatograph in a direct samp...

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Hauptverfasser: FAN ZHAOZE, CHEN LONG, YAO MENGXIA, LIU JUNJUN, HU RENJUN, YU YANPING, GONG DANFENG, ZHANG HENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for detecting triethylamine and N, N-diethylaniline in ceftazidime and application of the method. The detection method disclosed by the invention comprises the following steps: injecting a test solution containing ceftazidime into a gas chromatograph in a direct sample injection manner, recording a chromatogram, and calculating the content according to an external standard method; wherein the detection conditions of the chromatography are as follows: a chromatographic column is a capillary column taking modified dimethyl polysiloxane as a stationary liquid or a capillary chromatographic column with equivalent efficiency; the initial temperature is 95-105 DEG C, the temperature is maintained for 3 minutes, the temperature is raised to 220 DEG C at the rate of 10 DEG C per minute, and the temperature is maintained for 10 minutes. The method has good specificity and system adaptability, extremely low detection limit and quantitation limit, good linearity and good accuracy. 本发明公开了