In-vitro release detection method of ripdicaine emulsifiable paste

The invention discloses an in-vitro release detection method of ripdicaine emulsifiable paste, and belongs to the technical field of biological medicines. According to the method, a flow cell is adopted as an experimental device, a to-be-detected riprodicaine emulsifiable paste sample is placed in an emulsifiable paste pool, then a release film is placed in a fixing ring, the fixing ring and the emulsifiable paste pool are assembled to obtain an adapter, a release medium is added into a medium bottle, the flow speed and the water bath temperature of the flow cell are set, and sampling is carried out at fixed time for detection. According to the method, the quality difference of the ripdicaine emulsifiable paste is efficiently and accurately monitored through an in-vitro evaluation method, and the quality control difficulty of an imitated preparation is reduced. 本发明公开了一种利丙双卡因乳膏的体外释放检测方法，属于生物医药技术领域。该方法采用流通池为实验装置，将待测利丙双卡因乳膏样品置于乳膏池中，然后将释放膜放入固定环内，将固定环与软膏池组装得到适配器，向介质瓶中加入释放介质，设置流通池的流速和水浴温度，于固定时间取样进行检测。本发明实现了通过体外评价方法