Solid-phase extraction filler and preparation method thereof

The invention discloses a solid-phase extraction filler and a preparation method thereof, and belongs to the technical field of solid-phase extraction. According to the solid-phase extraction filler disclosed by the invention, monodisperse superparamagnetic crosslinked polystyrene microspheres are modified by using benzocarbazolyl methoxycarbonyl chloride, so that the solid-phase extraction filler which not only has magnetism but also can be combined with an amino compound is obtained. The filler overcomes the defects that the physical adsorption acting force is small, and an adsorbed target object is easily eluted by a weak solvent, and the solid-phase extraction filler and the target object are tightly combined and are not easily eluted by utilizing a chemical reaction, so that a better separation effect is obtained. 本发明公开了一种固相萃取填料及其制备方法，属于固相萃取技术领域。本发明的固相萃取填料，通过使用苯并咔唑基甲氧羰酰氯改性单分散超顺磁交联聚苯乙烯微球得到一种既有磁性，又能与胺基化合物结合的固相萃取填料。该填料克服了物理吸附作用力小，被吸附的目标物易被较弱的溶剂洗脱的缺点，利用化学反应，使得固相萃取填料与目标物紧密结合、不易洗脱，获得更好的分离效果。