FcRn gene humanized non-human animal as well as construction method and application thereof

The invention provides a humanized FcRn gene, a targeting vector, a construction method of an FcRn gene humanized non-human animal and application of the constructed non-human animal in the field of biological medicines. A nucleotide sequence partially coding human FcRn protein is introduced into a non-human animal genome in a homologous recombination manner; the humanized FcRn protein can be normally expressed in an animal body, and the humanized FcRn protein can be used as an animal model for human FcRn signal mechanism research and tumor and immune disease drug screening, and has important application value for new drug research and development of immune targets. 本发明提供了一种人源化FcRn基因、靶向载体以及FcRn基因人源化的非人动物的构建方法及其构建的非人动物在生物医药领域的应用，利用同源重组的方式将部分编码人FcRn蛋白的核苷酸序列导入非人动物基因组中，该动物体内能正常表达人源化FcRn蛋白，可以作为人FcRn信号机理研究、肿瘤及免疫性疾病药物筛选的动物模型，对免疫靶点的新药研发具有重要的应用价值。