Preparation method of propofol tenofovir dephenyl impurity

The invention is applicable to the technical field of drug synthesis, and provides a preparation method of a tenofovir propofol dephenyl impurity, which comprises the following steps: placing tenofovir propofol in a toluene/water/triethylamine system for hydrolysis reaction at the reaction temperature of 30-40 DEG C to obtain an impurity reaction liquid; diluted hydrochloric acid is added into the impurity reaction liquid to adjust the pH value, a crude product is separated out, the obtained crude product is subjected to triethylamine selective salification purification and impurity removal treatment in an acetone/water system, and the propofol tenofovir dephenyl impurity is obtained. The separation and purification method adopting diluted hydrochloric acid to adjust pH for crystallization and triethylamine to selectively form salt and remove impurities is adopted, so that the operation convenience is remarkably improved, the preparation cost is reduced, the method is efficient, simple, convenient and easy fo